Scientists print the first 3D heart with the patient’s own cells and materials
Research demonstrates the ability of engineering to approach individual tissue and organ replacement in the futureResearchers are now planning to preserve the hearts of labs and are teaching them to behave like hearts.
Researchers at Tel Aviv University have “printed” the world’s first three-dimensional (3D) vascular engineer hearts using a patient’s own cells and biological materials. His findings were published in a study in Advanced Science on April 15.
So far, scientists in regenerative medicine – an area positioned on the intersection of biology and technology – have succeeded in printing only simple tissues without blood vessels.
“This is the first time someone has successfully engineered anywhere and has printed the whole heart with cells, blood vessels, ventricles and chambers,” Prof. T.A. of School of Molecular Cell Biology and Biotechnology, TAU. Tal Talwire, who led the research for the study.
Heart disease is the leading cause of death among both men and women in the United States. Heart transplantation is currently the only treatment available for end-stage cardiac failure patients. Looking at the hard reductions of heart donors, there is a need to develop new perspectives to regenerate the diseased heart.
“This heart is made from human cells and patient-specific biological materials. In our process, these materials work in the form of bioines, sugars and proteins made from substances that can be used for 3D printing of complex tissue models, ” Pro. April 15 Press statement.
In the beginning of 2017, a team of biomedical engineering researchers led by the University of Minnesota created a laser 3D-bioprinter patch to address this issue and help recover the scarred heart tissue after a heart attack . When the cell patch was placed on the mouse after a simulated heart attack, the researchers saw significant increase in functional capacity after just four weeks. Patch was made from stem cells and structural proteins (which do most of the cells and are necessary for the structure, function and regulation of body tissues and organs related to the heart), it was part of the heart and was absorbed in the body. , No further surgery is required.
According to Aver, while people have been able to 3D-print the structure of one heart in the past, they have not done this with cells or with blood vessels. “Our results show the ability of our approach to engineering personalized tissue and organ replacement in the future,” he said.
For research, patients received biopsy of fatty tissue. The tissue cellular and a cellular material were then separated. While the cells were resumed to become a pluripotent stem cell, the three-dimensional network of extracellular macromolecules such as collagen and glycoprotein, the external matrix (ECM) was processed into a personal hydrogel which acts as a printing “ink” used to do. After mixing with hydrogels, cells with blood vessels to create patient-specific, immune-cardiac cardiac patches and later, the cells were completely differentiated into cardiac or endothelial cells altogether.
Researchers are now planning to practice the hearts of labs and “behave” like hearts, according to Prof. Dwyer. They then plan to transplant the 3D-printed heart into animal models. They hope that in the next decade, the best hospitals in the world will be organ printers and these processes will be organized regularly.
3D printing is related to a class of technology, known as additive manufacturing, or objects are created by the layer. Today, 3D printers not only make ornaments and toothbrushes, but also football shoes, racing-car parts, custom-designed cakes, human organs, homes, parts of airplanes and even more efficient lithium-ions Batteries also make. and yes! They also provide blueprints for 3D printed guns. Five years ago, Indian plastic surgeons at the Jawaharlal Institute of Postgraduate Medical Education and Research (Jipmer) in Puducherry, with the help of 3D printer, restored the distorted skull of a three-year-old girl in its original shape.